The RSC functions as the headquarters of the Netherlands American Studies Association (NASA).
Since its founding in 1977 the NASA has fulfilled an important role in bringing students and scholars together through its newsletter, its website, and its regular seminars and conferences. Its international connections via the European Association for American Studies have resulted in an increasing network of scholars who have passed through Middelburg for research, events, and collaborative projects. The RSC was closely involved in the establishment of the EAAS peer-reviewed publication, the European Journal of American Studies (EJAS), and from 2006 to 2011 RSC staff served as editors of EJAS.

The Center also participates in the broader field of transatlantic academic networks. It is a founding member of the American Studies Network, an alliance of about twenty American Studies Centers in Europe. The RSC also participates with the Transatlantic Studies Association (TSA), the Historians of the Twentieth Century United States (HOTCUS), and the Organization of American Historians (OAH).